49ers 2025 Opponents Synonym. Purdy, pearsall shine in 49ers’ loss to lions; The san francisco 49ers' 2024 season is almost over and, following their monday night football loss to the detroit lions in week 17, they now know the identity of every team they will face in 2025.

Following their week 17 matchup versus the detroit lions, the san francisco 49ers will close out the year as the no. The san francisco 49ers will receive a slight reprieve in the 2025 season thanks to their abysmal 2024 campaign.